Scientific Consensus on Cognitive Ability?

From the web site of the International Society for Intelligence Research (ISIR): a summary of the recent debate involving Charles Murray, Sam Harris, Richard Nisbett, Eric Turkheimer, Paige Harden, Razib Khan, Bo and Ben Winegard, Brian Boutwell, Todd Shackelford, Richard Haier, and a cast of thousands! ISIR is the main scientific society for researchers of …

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Genetics, Cognitive Ability, and Education (conversation with Cambridge PhD candidate Daphne Martschenko)

Genetics, Cognitive Ability, and Education (conversation with Cambridge PhD candidate Daphne Martschenko) Further conversation with Cambridge PhD candidate Daphne Martschenko concerning genetics of cognitive ability, implications for education policy, etc. See also earlier conversation: https://www.youtube.com/watch?v=YVqkvHpLfuQ Dunedin paper referenced in the video (polygenic score prediction of adult success for different SES groups): http://infoproc.blogspot.com/2016/09/genomic-prediction-of-adult-life.html Tweet

EQ, IQ, and all that

This Quora answer, from a pyschology professor who works on personality psychometrics, illustrates well the difference between rigorous and non-rigorous research in this area. Some years ago a colleague and I tried to replicate Duckworth’s findings on Grit, but to no avail, although IIRC our sample size was roughly as large as hers. In our …

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Flipping DNA switches

The recently published SSGAC study (Nature News) found 74 genome-wide significant hits related to educational attainment, using a discovery sample of ~300k individuals. The UK Biobank sample of ~110k individuals was used as a replication check of the results. If both samples are combined as a discovery sample 162 SNPs are identified at genome-wide significance. …

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74 SNP hits from SSGAC GWAS

The SSGAC discovery of 74 SNP hits on educational attainment (EA) is finally published in Nature. Nature News article. EA was used in order to assemble as large a sample as possible (~300k individuals). Specific cognitive scores are only available for a much smaller number of individuals. But SNPs associated with EA are likely to …

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BBC interview with Robert Plomin

I recommend this BBC interview with Robert Plomin. Robert is a consummate gentleman and scholar, working in a field that inevitably attracts controversy. (Via Dominic Cummings.) Professor Robert Plomin talks to Jim Al-Khalili about what makes some people smarter than others and why he’s fed up with the genetics of intelligence being ignored. Born and …

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IQ prediction from structural MRI

These authors use machine learning techniques to build sparse predictors based on grey/white matter volumes of specific regions. Correlations obtained are ~ 0.7 (see figure). I predict that genomic estimators of this kind will be available once ~ 1 million genomes and cognitive scores are available for analysis. See also Myths, Sisyphus and g. MRI-Based …

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More GWAS hits for cognitive ability

More genome-wide significant associations between individual SNPs and cognitive ability from a sample of 50k individuals. See also First GWAS hits for cognitive ability. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949) Nature Molecular Psychiatry advance online publication 3 February 2015 doi: 10.1038/mp.2014.188 General …

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Rare mutations and severe intellectual disability

The paper below describes rare de novo mutations which cause severe intellectual disability. See also Structural genomic variants (CNVs) affect cognition. By the principle of continuity, I suspect that rare variants of smaller negative effect on cognitive ability also exist. These alleles, although harder to detect, would account for part of the observed population variation in …

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Reserve and Resiliancy

Indemnity by Cognitive and Physical Activity I remember reading about Bird Flu about a decade ago when an unusual case came to light. The most pathogenic form was sweeping through Asia, and fourteen people came down with the disease that winter in Vietnam. The only person to survive was Nguyen Thanh Hung. Doctors believed that he may …

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