CRISPR edits in human zygotes

Results such as these had been the subject of rumors for some time. Also covered in Nature News. It is very early days for this technology — the off-target rate can probably be reduced significantly using better methods. But in the near term, safety and efficacy issues make PGD a better technique for improving human …

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CRISPR patent fight

Earlier CRISPR posts. MSU symposium with video (Patrick Hsu, one of the speakers (no relation), is from the Zhang lab). Technology Review: Discovery of the Century? There’s a bitter fight over the patents for CRISPR, a breakthrough new form of DNA editing. … In April of this year, Zhang and the Broad won the first of several sweeping patents that cover …

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Genetic engineering of monkeys using CRISPR

For earlier CRISPR posts, see here. Off-target mutations seem to be under control in this study. Technology Review. Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos (DOI:10.1016/j.cell.2014.01.027) Monkeys serve as important model species for studying human diseases and developing therapeutic strategies, yet the application of monkeys in biomedical researches has been …

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The dawn of genetic engineering?

Some CRISPR links. This technology is for real. See earlier post CRISPR. Watch realtime action here. GeCKO knockout in human cells. Zhang and Church raise $43M for new venture Editas. Application to Cystic Fibrosis in human stem cells , Cataracts in mouse. The Scientist: It was less than a year ago that scientists first applied CRISPR, a …

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