Multiallelic copy number variation

These new results probe surprisingly large variation in copy number (duplicated genomic segments) and its impact on gene expression. Earlier posts involving CNVs. Large multiallelic copy number variations in humans Nature Genetics (2015) doi:10.1038/ng.3200 Thousands of genomic segments appear to be present in widely varying copy numbers in different human genomes. We developed ways to …

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Adaptive evolution and non-coding regions

This morning I attended an excellent talk: Adaptive Evolution of Gene Expression (see paper and video below), by Hunter Fraser of Stanford. His results support the hypothesis that non-coding regions of the genome play at least as large a role in evolution and heritable variation as protein coding genes. From an information-theoretic perspective, it seems …

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ASBMB Special Symposium hosted by GEDD July 25-28

“Nothing in biology makes sense except in the light of evolution” – an insight from fly geneticist Theodosius Dobzhansky that underscores how evolutionary insights permeate all aspects of biological research. Faculty from the Michigan State University Gene Expression in Development and Disease Focus Group hosted a special symposium through the American Society of Biochemistry and …

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