A few months ago, I wrote a short description of how we make our papers replicable in the lab. One problem with this process is that for complex pipelines, it’s not always obvious how to connect a number in the paper to the steps in the pipeline that produced it — there are lots of …
I just took part in a twitter discussion about the trade-offs between sequencing depth and number of independent biological replicate (per treatment group) for differential gene expression analysis. While there are applications of RNA-seq where sequencing deeply (more than say 50 million reads for a given sample) can be important for discovery. However, most researchers …
In a blog post from December of 2013, I described our attempts to replicate two studies testing the claim that priming cleanliness makes participants less judgmental on a series of 6 moral vignettes. My original post has recently received criticism for my timing and my tone. In terms of timing, I blogged about a paper …
The economist just published a pair of articles broadly about the state of affairs in scientific research (and from their perspective everything is in a tail spin). “How Science Goes Wrong” and ” Trouble at the lab“. Both articles are worth reading, although few will find themselves in agreement with all of their conclusions. Neither …